Parasitol Res 112 Suppl 1, 57-66 PubMed. To compare the efficacy of two spot‐on treatments of moxidectin/imidacloprid, two weeks apart to a single oral dose of fluralaner against Lynxacarus radovskyi and evaluate time to re‐infestation. Available in packs containing 3 and 6 pipettes of 0.4 and 0.8mL dose sizes.ActionImidacloprid exerts its effect by binding to post synaptic nicotinic receptors, blocking Each milliliter of constituted, sustained-release suspension contains 3.4 mg of moxidectin The formulation Advantage Multi for dogs 2.5% (25mg/mL) includes 25% Imidacloprid. Excipients: Benzyl alcohol . Please refer to section 4.5. imidacloprid / moxidectin) An overview of Advocate and why it is authorised in the EU . (1.0 mg/kg) moxidectin once a month by topical administration. This is a common over-the-counter medication used to prevent fleas and heartworms in dogs as well as ear mites in cats. Moxiclear spot-on solution for large cats. Directions for use: Use the top of the cap to break seal of tube. For ferrets: Do not use Endectrid for large cats (0.8 ml) or Endectrid for dogs (any size). Legal Category POM-V. 4.4 Special warnings for each target species. Advocate is a medicine used on cats, ferrets and dogs suffering from, or at risk from, mixed parasitic infections (caused by several different types of parasites): Each tube contains: IMIDACLOPRID & MOXIDECTIN. Advantage Multi® (imidaclopid + moxidectin) Discover how Advantage Multi® has an innovative transdermal formula with imidacloprid + moxidectin for monthly flea protection. General Description: Imidacloprid + moxidectin is a topical insecticide and endectocide agent used in dogs and cats once a month to treat and control fleas, heartworms, hookworms and roundworms. Administer the entire contents of the Advantage Multi ® for Cats tube that correctly corresponds with the body weight of the cat. CAUTION: Federal (U.S.A.) law restricts Advantage Multi® for Dogs to use by or on the order of a licensed veterinarian. For cats, the recommended minimum dose is 4.5 mg/lb. Cats: Imidacloprid plus moxidectin comes in 3 different sizes for cats and is dosed according to weight. A single treatment with this formulation also provided 88.4-100% control of adult C. felis for 35 days. Do not exceed the recommended dose. The recommended minimum doses for cats are 10 mg/kg body weight imidacloprid and 1.0 mg/kg body weight moxidectin, equivalent to 0.1ml/kg body weight Advocate for cats. Active Ingredient For dogs, the corresponding “Endectrid for dog” product, which contains 100 mg/ml imidacloprid and 25 mg/ml moxidectin, must be used. IMIDACLOPRID: 100 mg/mL (= 10.0%) MOXIDECTIN: 25 mg/mL for dogs (= 2.5%) 10 mg/mL for cats (= 1.0%) CHEMICAL CLASS of the active ingredient(s): Imidacloprid: NEONICOTINOID; Moxidectin: MACROCYCLIC LACTONE Do not use on canaries. In this study, the efficacy and safety of a treatment with the combination imidacloprid 10 %/ moxidectin 1.0 % spot-on (Advocate(®) spot-on for small cats and ferrets) was tested in 39 ferrets naturally infested with ear mites (Otodectes cynotis). (10.0 mg/kg) imidacloprid and 0.45 mg/lb. The formulation containing 10% imidacloprid and 1% moxidectin was 100% efficacious against the development of adult D. immitis infections when cats were treated 30 days after inoculation with third-stage larvae. The study was performed as a multicentre, non-random … Advantage Multi ® for Dogs (10% imidacloprid + 2.5% moxidectin) is a colorless to yellow ready-to-use solution packaged in single dose applicator tubes for topical treatment of dogs. Advantage Multi ® for Cats (10% imidacloprid + 1% moxidectin) is a colorless to yellow ready-to-use solution packaged in single-dose applicator tubes for topical treatment of cats. Place the tip of the tube on the skin and squeeze tube firmly to apply solution directly to the skin. Overview of Advantage Multi™ for Canines and Felines Imidacloprid and Moxidectin is a combination of drugs commonly known as Advantage Multi™. Moxidectin also affects the nervous system in parasites and protects against heartworms. Imidacloprid is a chloronicotinyl nitroguanidine insecticide. Imidacloprid is used on and off label and is applied topically to the skin to treat flea infestations. Resources. The results of this study demonstrate that imidacloprid+moxidectin topical solution can be used safely in cats heavily infected with adult D. immitis. There were no statistically significant differences in the comparison of adult D. immitis recovered at necropsy (ANOVA overall group effect P-value of 0.5356). Do not use on canaries. For Kittens, Small Cats & Ferrets up to 4 kg . For ferrets: Do not use Endectrid for large cats (0.8 ml) or Endectrid for dogs (any size). Advantage Multi for Cats (10% imidacloprid + 1% moxidectin) is a colorless to yellow ready-to-use solution packaged in single-dose applicator tubes for topical treatment of cats. The treatment schedule for all species should be based on individual veterinary diagnoses and on the local epidemiological situation. Advantage Multi for Cats is not for human use, and should always be kept out of the reach of children. 4.4 Special warnings for each target species. Advocate for cats contains 100 mg/ml imidacloprid and 10 mg/ml moxidectin. This product may also be used monthly for prevention of heartworm infection and to treat flea infestations in ferrets. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin based on body weight. Objectives. cats. It is frequently used in combination with other medications to treat a variety of parasites. In this study, the efficacy and safety of a treatment with the combination imidacloprid 10 %/ moxidectin 1.0 % spot-on (Advocate® spot-on for small cats and ferrets) was tested in 39 ferrets naturally infested with ear mites (Otodectes cynotis). For Cats Over 4kg. METHODS: Cats were experimentally inoculated with 300-800 third-stage larvae (L3). The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin based on body weight. The recommended minimum doses are 10 mg/kg bodyweight imidacloprid and 1.0 mg/kg bodyweight moxidectin, equivalent to 0.1 ml/kg bodyweight Advocate for cats. Advocate for Cats Over 4 kgActive ingredientsImidacloprid 100g/L and moxidectin 10g/L solution for topical application onto cats. Do not let animal lick treated area; keep other pets and children away from treated animals until the area has dried (about 30 Lynxacarus radovskyi has been observed in cats in Malaysia; previously treatment with fipronil and moxidectin/imidacloprid spot‐on has been described.. Each group comprised 8 animals and the treatment dose was 10 mg/kg bodyweight (bw) imidacloprid and 1 mg/kg bw moxidectin in each study. Hellmann K, Petry G, Capari B, Cvejic D, Krämer F (2013) Treatment of naturally Notoedres cati-infested cats with a combination of imidacloprid 10 % / moxidectin 1 % spot-on (Advocate® / Advantage® Multi, Bayer). Imidacloprid and moxidectin is not recommended for animals that are nursing, pregnant, debilitated, or geriatric. Weight of cat [kg] Pipette size to be used Volume [ml] Imidacloprid [mg/kg bw] Moxidectin [mg/kg bw] Advantage Multi for cats 1% (10mg/mL) includes 10% Imidacloprid. Available in packs of 3 or 6 . It will also treat and control whipworms in dogs and ear mites in cats. Ferrets: Imidacloprid plus moxidectin for ferrets and is dosed according to weight. Avoid any type of skin contact with the application site for 30 minutes following treatment with this topical flea medication. The efficacy and safety of a combination formulation of 10% imidacloprid + 1.0% moxidectin spot-on (Advocate® for Cats, Bayer Animal Health GmbH, Leverkusen, Germany) was tested in 40 African pygmy hedgehogs (Atelerix albiventris) naturally infested with Caparinia tripilis. The chemical name of imidacloprid is 1-[(6-Chloro-3-pyridinyl)methyl]-N-nitro-2-imidazolidinimine. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin based on body weight. Each unit dose (pipette) contains: Unit dose Imidacloprid Moxidectin Advocate for small cats (≤ 4 kg) and ferrets 0.4 ml 40 mg 4 mg Advocate for large cats (> 4–8 kg) 0.8 ml 80 mg 8 mg . The recommended minimum dose is 10 milligrams per kilogram imidacloprid and 1 milligram per kilogram moxidectin once a month by topical administration. Imidacloprid plus moxidectin (Advantage® Multi for Cats, Bayer) was used as a positive control in both studies at the label dosage. The recommended minimum doses for cats are 10mg/kg body weight imidacloprid and 1.0mg/kg body weight moxidectin, equivalent to 0.1ml/kg body weight Endectrid for Cats. Two studies were conducted to evaluate and compare the efficacy of imidacloprid + moxidectin and selamectin topical solutions against the KS1 flea strain infesting cats. Moxiclear is broad spectrum endectocide spot-on for very large cats (>4 ≤ 8 kg) containing imidacloprid and moxidectin. Advantage Multi® for Cats (10 % imidacloprid + 1 % moxidectin) is a colorless to yellow ready-to-use solution packaged in single-dose applicator tubes for topical treatment of cats. Butylhydroxytoluene 1 mg/ml (E 321; as antioxidant). The treatment schedule should be based on the local epidemiological situation. Advantage Multi ® for Cats (10% imidacloprid + 1% moxidectin) is a colorless to yellow ready-to-use solution packaged in single-dose applicator tubes for topical treatment of cats. What is Advocate and what is it used for? Side effects are uncommon but may include irritation at the application site, or, if the medication is accidentally ingested, drooling, shaking, vomiting, and decreased appetite. Please refer to section 4.5. Imidacloprid attacks the nervous system in insects, which causes impairment and subsequently death. Cautions. Imidacloprid + moxidectin is applied between the shoulder blades every thirty days. Background. 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